Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788.

Published

Journal Article

Three experiments were carried out in rats to evaluate the analgesic effects of the benzodiazepine antagonist, Ro 15-1788. Expt. 1 demonstrated a diazepam reversible analgesic effect of Ro 15-1788 using the tail-flick test. Expt. 2 analyzed the effects of Ro 15-1788 in the hot-plate test at various doses. Low doses of Ro 15-1788 proved analgesia 20 min after drug injection, whereas high doses had no analgesic effect on the 20 min test, but were effective on the 50 min test. Expt. 3 demonstrated that the opiate antagonist, naloxone, had no effect on analgesia produced by Ro 15-1788 in the hot-plate test. The analgesic effects of Ro 15-1788 may be attributable to its reported anxiogenic properties.

Full Text

Duke Authors

Cited Authors

  • Morgan, MM; Levin, ED; Liebeskind, JC

Published Date

  • July 14, 1987

Published In

Volume / Issue

  • 415 / 2

Start / End Page

  • 367 - 370

PubMed ID

  • 3111641

Pubmed Central ID

  • 3111641

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(87)90222-8

Language

  • eng

Conference Location

  • Netherlands