Psychopharmacological effects in the radial-arm maze.


Journal Article (Review)

The radial-arm maze (RAM) has become a very widely used method for assessing spatial memory in rodents. It has proven to be quite useful in the investigation of the effects of a variety of pharmacological manipulations on spatial memory. The cholinergic system has been found to be crucial for accurate RAM performance. Blockade of either muscarinic or nicotinic receptors impairs performance. Other transmitter systems such as dopamine and the opiates have also been found to be involved with the maintenance of accurate RAM performance. This test has been found to be sensitive to the effects of a variety of toxicants given either in adulthood or during development. These findings provide a background for the assessment of the effects of novel substances on RAM performance as well as the basis for the further understanding of the neural substrates of memory.

Full Text

Duke Authors

Cited Authors

  • Levin, ED

Published Date

  • 1988

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 169 - 175

PubMed ID

  • 2902540

Pubmed Central ID

  • 2902540

International Standard Serial Number (ISSN)

  • 0149-7634

Digital Object Identifier (DOI)

  • 10.1016/s0149-7634(88)80008-3


  • eng

Conference Location

  • United States