Heterogeneity of toxicant response: sources of human variability.
Publication
, Journal Article
Aldridge, JE; Gibbons, JA; Flaherty, MM; Kreider, ML; Romano, JA; Levin, ED
Published in: Toxicol Sci
November 2003
While risk assessment models attempt to predict human risk to toxicant exposure, in many cases these models cannot account for the wide variety of human responses. This review addresses several primary sources of heterogeneity that may affect individual responses to drug or toxicant exposure. Consideration was given to genetic polymorphisms, age-related factors during development and senescence, gender differences associated with hormonal function, and preexisting diseases influenced by toxicant exposure. These selected examples demonstrate the need for additional steps in risk assessment that are needed to more accurately predict human responses to toxicants and drugs.
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Published In
Toxicol Sci
DOI
ISSN
1096-6080
Publication Date
November 2003
Volume
76
Issue
1
Start / End Page
3 / 20
Location
United States
Related Subject Headings
- Toxicology
- Sex Factors
- Risk Assessment
- Humans
- Genetic Predisposition to Disease
- Environmental Pollutants
- Drug-Related Side Effects and Adverse Reactions
- Cytochrome P-450 Enzyme System
- Age Factors
- 3214 Pharmacology and pharmaceutical sciences
Citation
APA
Chicago
ICMJE
MLA
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Aldridge, J. E., Gibbons, J. A., Flaherty, M. M., Kreider, M. L., Romano, J. A., & Levin, E. D. (2003). Heterogeneity of toxicant response: sources of human variability. Toxicol Sci, 76(1), 3–20. https://doi.org/10.1093/toxsci/kfg204
Aldridge, Justin E., Jennifer A. Gibbons, Meghan M. Flaherty, Marisa L. Kreider, Jocelyn A. Romano, and Edward D. Levin. “Heterogeneity of toxicant response: sources of human variability.” Toxicol Sci 76, no. 1 (November 2003): 3–20. https://doi.org/10.1093/toxsci/kfg204.
Aldridge JE, Gibbons JA, Flaherty MM, Kreider ML, Romano JA, Levin ED. Heterogeneity of toxicant response: sources of human variability. Toxicol Sci. 2003 Nov;76(1):3–20.
Aldridge, Justin E., et al. “Heterogeneity of toxicant response: sources of human variability.” Toxicol Sci, vol. 76, no. 1, Nov. 2003, pp. 3–20. Pubmed, doi:10.1093/toxsci/kfg204.
Aldridge JE, Gibbons JA, Flaherty MM, Kreider ML, Romano JA, Levin ED. Heterogeneity of toxicant response: sources of human variability. Toxicol Sci. 2003 Nov;76(1):3–20.
Published In
Toxicol Sci
DOI
ISSN
1096-6080
Publication Date
November 2003
Volume
76
Issue
1
Start / End Page
3 / 20
Location
United States
Related Subject Headings
- Toxicology
- Sex Factors
- Risk Assessment
- Humans
- Genetic Predisposition to Disease
- Environmental Pollutants
- Drug-Related Side Effects and Adverse Reactions
- Cytochrome P-450 Enzyme System
- Age Factors
- 3214 Pharmacology and pharmaceutical sciences