The effect of halothane on cultured fibroblasts and neuroblastoma cells.

Journal Article (Journal Article)

Halothane exposure over the cultured cells (100 and 1,000 ppm) caused a disruption of the pattern of actin distribution in both fibroblasts and neuroblastoma cells. Neuroblastoma cells exposed to halothane also lost microspikes; however, neurite elongation was not affected by halothane. The present study suggests that halothane induces the functional disruption of actin, resulting in an interference of normal neural development in vivo.

Full Text

Duke Authors

Cited Authors

  • Uemura, E; Levin, ED

Published Date

  • September 28, 1992

Published In

Volume / Issue

  • 145 / 1

Start / End Page

  • 33 - 36

PubMed ID

  • 1461563

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(92)90196-e


  • eng

Conference Location

  • Ireland