Skip to main content
Journal cover image

Transdermal nicotine facilitates smoking cessation.

Publication ,  Journal Article
Rose, JE; Levin, ED; Behm, FM; Adivi, C; Schur, C
Published in: Clin Pharmacol Ther
March 1990

The efficacy of a transdermal nicotine patch in facilitation of smoking cessation was evaluated in a randomized double-blind trial. Sixty-five smokers who were highly dependent on cigarettes participated in the study, which included a behavioral smoking-cessation program. The rates of continuous abstinence were significantly higher in the nicotine group both initially (55% versus 34%) and at 3 weeks (18% versus 6%). Certain smoking withdrawal symptoms, including negative affect and hypoarousal, were effectively relieved by the nicotine patch. There was a trend toward a reduction in cigarette craving, whereas hunger and habit withdrawal symptoms were not affected. The main side effect associated with the nicotine patch was skin irritation. These findings suggest that a nicotine skin patch may be a useful aid to smoking cessation; however, the combination of other techniques with nicotine replacement may provide a more effective treatment for symptoms such as craving for cigarettes.

Duke Scholars

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

March 1990

Volume

47

Issue

3

Start / End Page

323 / 330

Location

United States

Related Subject Headings

  • Tobacco Use Disorder
  • Smoking Prevention
  • Randomized Controlled Trials as Topic
  • Pharmacology & Pharmacy
  • Nicotine
  • Male
  • Humans
  • Female
  • Double-Blind Method
  • Administration, Cutaneous
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rose, J. E., Levin, E. D., Behm, F. M., Adivi, C., & Schur, C. (1990). Transdermal nicotine facilitates smoking cessation. Clin Pharmacol Ther, 47(3), 323–330. https://doi.org/10.1038/clpt.1990.35
Rose, J. E., E. D. Levin, F. M. Behm, C. Adivi, and C. Schur. “Transdermal nicotine facilitates smoking cessation.Clin Pharmacol Ther 47, no. 3 (March 1990): 323–30. https://doi.org/10.1038/clpt.1990.35.
Rose JE, Levin ED, Behm FM, Adivi C, Schur C. Transdermal nicotine facilitates smoking cessation. Clin Pharmacol Ther. 1990 Mar;47(3):323–30.
Rose, J. E., et al. “Transdermal nicotine facilitates smoking cessation.Clin Pharmacol Ther, vol. 47, no. 3, Mar. 1990, pp. 323–30. Pubmed, doi:10.1038/clpt.1990.35.
Rose JE, Levin ED, Behm FM, Adivi C, Schur C. Transdermal nicotine facilitates smoking cessation. Clin Pharmacol Ther. 1990 Mar;47(3):323–330.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

March 1990

Volume

47

Issue

3

Start / End Page

323 / 330

Location

United States

Related Subject Headings

  • Tobacco Use Disorder
  • Smoking Prevention
  • Randomized Controlled Trials as Topic
  • Pharmacology & Pharmacy
  • Nicotine
  • Male
  • Humans
  • Female
  • Double-Blind Method
  • Administration, Cutaneous