Transdermal nicotine facilitates smoking cessation.

Journal Article (Clinical Trial;Journal Article)

The efficacy of a transdermal nicotine patch in facilitation of smoking cessation was evaluated in a randomized double-blind trial. Sixty-five smokers who were highly dependent on cigarettes participated in the study, which included a behavioral smoking-cessation program. The rates of continuous abstinence were significantly higher in the nicotine group both initially (55% versus 34%) and at 3 weeks (18% versus 6%). Certain smoking withdrawal symptoms, including negative affect and hypoarousal, were effectively relieved by the nicotine patch. There was a trend toward a reduction in cigarette craving, whereas hunger and habit withdrawal symptoms were not affected. The main side effect associated with the nicotine patch was skin irritation. These findings suggest that a nicotine skin patch may be a useful aid to smoking cessation; however, the combination of other techniques with nicotine replacement may provide a more effective treatment for symptoms such as craving for cigarettes.

Full Text

Duke Authors

Cited Authors

  • Rose, JE; Levin, ED; Behm, FM; Adivi, C; Schur, C

Published Date

  • March 1990

Published In

Volume / Issue

  • 47 / 3

Start / End Page

  • 323 - 330

PubMed ID

  • 2178852

International Standard Serial Number (ISSN)

  • 0009-9236

Digital Object Identifier (DOI)

  • 10.1038/clpt.1990.35


  • eng

Conference Location

  • United States