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Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease.

Publication ,  Journal Article
Rusted, JM; Newhouse, PA; Levin, ED
Published in: Behav Brain Res
August 2000

Nicotinic systems play an important role in the neural basis of working memory and attention. Recent progress in understanding of the structure, function, and distribution of central nervous system (CNS) nicotinic receptors and their pharmacology has opened up new possibilities for novel CNS therapeutics with nicotinic agents. In this paper, we review the theoretical justification and the experimental evidence supporting these developments. We focus on the applications of nicotinic agonists in CNS disorders that are degenerative in nature, namely Parkinson's disease and Alzheimer's disease. We suggest that there is considerable potential for therapeutic applications in the near future. Clinically, two major issues remain: (a) the selectivity of effects, that is, developing compounds which are selective in producing improvement in cognition, motor function, attention, or pain without significant side-effects; and (b) the realistic likelihood of long-term improvements in everyday functioning in people who have degenerative diseases.

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Published In

Behav Brain Res

DOI

ISSN

0166-4328

Publication Date

August 2000

Volume

113

Issue

1-2

Start / End Page

121 / 129

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Receptors, Nicotinic
  • Parkinson Disease
  • Nicotinic Agonists
  • Neurology & Neurosurgery
  • Humans
  • Brain
  • Animals
  • Alzheimer Disease
  • 5202 Biological psychology
 

Citation

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Rusted, J. M., Newhouse, P. A., & Levin, E. D. (2000). Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease. Behav Brain Res, 113(1–2), 121–129. https://doi.org/10.1016/s0166-4328(00)00207-2
Rusted, J. M., P. A. Newhouse, and E. D. Levin. “Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease.Behav Brain Res 113, no. 1–2 (August 2000): 121–29. https://doi.org/10.1016/s0166-4328(00)00207-2.
Rusted JM, Newhouse PA, Levin ED. Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease. Behav Brain Res. 2000 Aug;113(1–2):121–9.
Rusted, J. M., et al. “Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease.Behav Brain Res, vol. 113, no. 1–2, Aug. 2000, pp. 121–29. Pubmed, doi:10.1016/s0166-4328(00)00207-2.
Rusted JM, Newhouse PA, Levin ED. Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease. Behav Brain Res. 2000 Aug;113(1–2):121–129.
Journal cover image

Published In

Behav Brain Res

DOI

ISSN

0166-4328

Publication Date

August 2000

Volume

113

Issue

1-2

Start / End Page

121 / 129

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Receptors, Nicotinic
  • Parkinson Disease
  • Nicotinic Agonists
  • Neurology & Neurosurgery
  • Humans
  • Brain
  • Animals
  • Alzheimer Disease
  • 5202 Biological psychology