Correction of purine nucleoside phosphorylase deficiency by transplantation of allogeneic bone marrow from a sibling.
Publication
, Journal Article
Broome, CB; Graham, ML; Saulsbury, FT; Hershfield, MS; Buckley, RH
Published in: J Pediatr
March 1996
Deficiency of the purine salvage pathway enzyme purine nucleoside phosphorylase causes a combined immunodeficiency and neurologic abnormalities and is usually fatal in childhood. We report the first successful transplantation of bone marrow from a sibling with identical class II human leukocyte antigens in this condition, demonstrating correction of both lymphocyte metabolic and functional abnormalities.
Duke Scholars
Published In
J Pediatr
DOI
ISSN
0022-3476
Publication Date
March 1996
Volume
128
Issue
3
Start / End Page
373 / 376
Location
United States
Related Subject Headings
- Transplantation, Homologous
- Time Factors
- Purine-Pyrimidine Metabolism, Inborn Errors
- Purine-Nucleoside Phosphorylase
- Pediatrics
- Immunologic Deficiency Syndromes
- Humans
- Histocompatibility Testing
- Follow-Up Studies
- Child
Citation
APA
Chicago
ICMJE
MLA
NLM
Broome, C. B., Graham, M. L., Saulsbury, F. T., Hershfield, M. S., & Buckley, R. H. (1996). Correction of purine nucleoside phosphorylase deficiency by transplantation of allogeneic bone marrow from a sibling. J Pediatr, 128(3), 373–376. https://doi.org/10.1016/s0022-3476(96)70285-8
Broome, C. B., M. L. Graham, F. T. Saulsbury, M. S. Hershfield, and R. H. Buckley. “Correction of purine nucleoside phosphorylase deficiency by transplantation of allogeneic bone marrow from a sibling.” J Pediatr 128, no. 3 (March 1996): 373–76. https://doi.org/10.1016/s0022-3476(96)70285-8.
Broome CB, Graham ML, Saulsbury FT, Hershfield MS, Buckley RH. Correction of purine nucleoside phosphorylase deficiency by transplantation of allogeneic bone marrow from a sibling. J Pediatr. 1996 Mar;128(3):373–6.
Broome, C. B., et al. “Correction of purine nucleoside phosphorylase deficiency by transplantation of allogeneic bone marrow from a sibling.” J Pediatr, vol. 128, no. 3, Mar. 1996, pp. 373–76. Pubmed, doi:10.1016/s0022-3476(96)70285-8.
Broome CB, Graham ML, Saulsbury FT, Hershfield MS, Buckley RH. Correction of purine nucleoside phosphorylase deficiency by transplantation of allogeneic bone marrow from a sibling. J Pediatr. 1996 Mar;128(3):373–376.
Published In
J Pediatr
DOI
ISSN
0022-3476
Publication Date
March 1996
Volume
128
Issue
3
Start / End Page
373 / 376
Location
United States
Related Subject Headings
- Transplantation, Homologous
- Time Factors
- Purine-Pyrimidine Metabolism, Inborn Errors
- Purine-Nucleoside Phosphorylase
- Pediatrics
- Immunologic Deficiency Syndromes
- Humans
- Histocompatibility Testing
- Follow-Up Studies
- Child