S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity.

Journal Article (Journal Article)

When adenosine deaminase activity is inhibited, low concentrations of adenosine are toxic to human lymphoblast mutants that are unable to convert adenosine to intracellular nucleotides. In order to identify the mediator of this cytotoxicity, we searched for a cytoplasmic protein capable of binding adenosine with high affinity. Such a protein was identified in extracts of human lymphoblasts and placenta as the enzyme S-adenosylhomocysteine hydrolase.

Full Text

Duke Authors

Cited Authors

  • Hershfield, MS; Krodich, NM

Published Date

  • November 17, 1978

Published In

Volume / Issue

  • 202 / 4369

Start / End Page

  • 757 - 760

PubMed ID

  • 715439

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.715439


  • eng

Conference Location

  • United States