Role of structural organization in the urine concentrating mechanism of an avian kidney.


Journal Article

The organization of tubules and blood vessels in the quail medullary cone is highly structured. This structural organization may result in preferential interactions among tubules and vessels, interactions that may enhance urine concentrating capability. In this study, we formulate a model framework for the urine concentrating mechanism of the quail kidney. The model simulates preferential interactions among renal tubules by representing two concentric cores and by specifying the fractions of tubules assigned to each of the concentric cores. The model equations are based on standard expressions for transmural transport and on solute and water conservation. Model results suggest that the preferential interactions among tubules enhance the urine concentration capacity of short medullary cones by reducing the diluting effect of the descending limbs on the region of the interstitium where the collecting ducts are located; however, the effects on longer cones are unclear.

Full Text

Duke Authors

Cited Authors

  • Layton, AT

Published Date

  • October 2005

Published In

Volume / Issue

  • 197 / 2

Start / End Page

  • 211 - 230

PubMed ID

  • 16135372

Pubmed Central ID

  • 16135372

Electronic International Standard Serial Number (EISSN)

  • 1879-3134

International Standard Serial Number (ISSN)

  • 0025-5564

Digital Object Identifier (DOI)

  • 10.1016/j.mbs.2005.07.004


  • eng