Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.

Journal Article

We report that vascular endothelial growth factor (VEGF), a major angiogenic factor, is also arequisite autocrine factor for breast carcinoma invasion in vitro and that the VEGF receptor Neuropilin-1 but not Flt-1 is essential for this function. VEGF regulates expression of the chemokine receptor CXCR4, and this VEGF target is needed for invasion but not for cell survival. CXCR4 mediates migration of breast carcinoma cells toward stromal-derived factor-1, and this migration is dependent on autocrine VEGF. Of interest, a CXCR4-inhibitory peptide that is currently in HIV clinical trials suppressed invasion. Our findings indicate that a VEGF autocrine pathway induces chemokine receptor expression in breast carcinoma cells, thus promoting their directed migration toward specific chemokines.

Full Text

Duke Authors

Cited Authors

  • Bachelder, RE; Wendt, MA; Mercurio, AM

Published Date

  • December 15, 2002

Published In

Volume / Issue

  • 62 / 24

Start / End Page

  • 7203 - 7206

PubMed ID

  • 12499259

International Standard Serial Number (ISSN)

  • 0008-5472

Language

  • eng

Conference Location

  • United States