The metastatic odyssey: the integrin connection.

Journal Article (Journal Article;Review)

This article explores the mechanistic basis of carcinoma progression by focusing on the contribution of integrins. Integrins are essential for progression because of their ability to mediate physical interactions with extracellular matrices and their ability to regulate signaling pathways that control actin dynamics and cell movement, and for growth and survival. This article centers on a6 integrins (a6B1 and a6B4), which are receptors for the laminin family of basement membrane components. Numerous studies have implicated these integrins in cancer progression and have provided a rationale for studying the mechanistic basis of their contribution to aggressive disease.

Full Text

Duke Authors

Cited Authors

  • Mercurio, AM; Bachelder, RE; Rabinovitz, I; O'Connor, KL; Tani, T; Shaw, LM

Published Date

  • April 2001

Published In

Volume / Issue

  • 10 / 2

Start / End Page

  • 313 - ix

PubMed ID

  • 11382589

International Standard Serial Number (ISSN)

  • 1055-3207


  • eng

Conference Location

  • United States