[Studies on formulations of Panax notoginsenosides for intranasal administration]

Journal Article (Academic article)

AIM: To develop high bioavailability preparations without irritation for Panax notoginsenosides. METHODS: The effects of some additives such as microcrystalline cellulose, beta-cyclodextrin and hydroxypropyl cellulose on drug in the preparations were examined. RESULTS: Saponins of Panax notoginseng (PNS) was absorbed in rabbits more when administered intranasally than through other routines, and the formulations including MCC both gave high bioavailability and low irritation. CONCLUSION: Bioavailability of Panax notoginsenosides can be increased through changing routine of administration and formulations.

Duke Authors

Cited Authors

  • Xu, QF; Fang, XL; Chen, DF; Li, JC

Published Date

  • November 2003

Published In

Volume / Issue

  • 38 / 11

Start / End Page

  • 859 - 862

International Standard Serial Number (ISSN)

  • 0513-4870

Conference Location

  • china