Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response.
Publication
, Journal Article
Li, JC; Lee, DC; Cheung, BK; Lau, AS
Published in: FEBS letters
June 2005
HIV Tat has been known to have multiple regulatory roles including replication of HIV and modulation of cellular kinases. We investigated whether signaling kinase PKR plays a critical role in mediating Tat-induced cytokine dysregulation. We showed Tat induction of IL-10 dysregulation is associated with PKR activation. To examine the mechanism involved, inhibition of PKR activity abrogated the Tat-induced cytokine induction. We next identified that the MAP kinases including ERK-1/2 and p38 are downstream of PKR in these Tat-induced pathways. Thus, PKR may play a critical role in mediating the subversive effects of HIV Tat resulting in IL-10 induction.
Duke Scholars
Published In
FEBS letters
ISSN
0014-5793
Publication Date
June 2005
Volume
579
Issue
14
Start / End Page
3055 / 3062
Location
netherlands
Related Subject Headings
- Biochemistry & Molecular Biology
- 0603 Evolutionary Biology
- 0601 Biochemistry and Cell Biology
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Li, J. C., Lee, D. C., Cheung, B. K., & Lau, A. S. (2005). Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response. FEBS Letters, 579(14), 3055–3062.
Li, J. C., D. C. Lee, B. K. Cheung, and A. S. Lau. “Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response.” FEBS Letters 579, no. 14 (June 2005): 3055–62.
Li JC, Lee DC, Cheung BK, Lau AS. Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response. FEBS letters. 2005 Jun;579(14):3055–62.
Li, J. C., et al. “Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response.” FEBS Letters, vol. 579, no. 14, June 2005, pp. 3055–62.
Li JC, Lee DC, Cheung BK, Lau AS. Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response. FEBS letters. 2005 Jun;579(14):3055–3062.
Published In
FEBS letters
ISSN
0014-5793
Publication Date
June 2005
Volume
579
Issue
14
Start / End Page
3055 / 3062
Location
netherlands
Related Subject Headings
- Biochemistry & Molecular Biology
- 0603 Evolutionary Biology
- 0601 Biochemistry and Cell Biology
- 0304 Medicinal and Biomolecular Chemistry