Lignan derivatives and a norditerpene from the seeds of Vitex negundo.

Journal Article (Academic article)

A new phenyldihydronaphthalene-type lignan, vitedoin A (1), a new phenylnaphthalene-type lignan alkaloid, vitedoamine A (2), and a new trinorlabdane-type diterpene, vitedoin B (3), were isolated from the seeds of Vitex negundo along with five known lignan derivatives (4-8). Their chemical structures were determined mainly on the basis of NMR and MS data. Compounds 1, 2, and 4-7 showed stronger antioxidative activity than alpha-tocopherol using the ferric thiocyanate method. Compounds 1, 2, and 4-7 showed higher radical-scavenging effect on the stable free radical, 1,1-diphenyl-2-picrylhydrazyl, than L-cysteine.

Duke Authors

Cited Authors

  • Ono, M; Nishida, Y; Masuoka, C; Li, JC; Okawa, M; Ikeda, T; Nohara, T

Published Date

  • December 2004

Published In

Volume / Issue

  • 67 / 12

Start / End Page

  • 2073 - 2075

International Standard Serial Number (ISSN)

  • 0163-3864

Conference Location

  • united states