The hypogonadotropic state of the prepubertal male rhesus monkey (Macaca mulatta) is not associated with a decrease in hypothalamic gonadotropin-releasing hormone content.
Journal Article (Journal Article)
Hypothalamic contents of gonadotropin-releasing hormone (GnRH) in neonatally orchidectomized infant, juvenile, and adult monkeys were measured by a radioimmunoassay (RIA) and by an in vivo bioassay that utilized luteinizing hormone (LH) secretion in estrogen- and progesterone-treated ovariectomized rats. The results of the bioassay provided no evidence to suggest that hypothalamic GnRH content in juvenile monkeys (mean = 83 ng/hypothalamus; n = 3) was less than that in infants (mean = 54 ng/hypothalamus; n = 4) and adults (mean = 36 ng/hypothalamus; n = 3). A similar developmental pattern in hypothalamic GnRH content was also observed when the decapeptide was measured by RIA. In striking contrast to the maintenance of hypothalamic GnRH content throughout postnatal development, pituitary gonadotropin contents and serum gonadotropin concentrations were markedly reduced in juvenile monkeys.
Full Text
Duke Authors
Cited Authors
- Fraser, MO; Pohl, CR; Plant, TM
Published Date
- May 1989
Published In
Volume / Issue
- 40 / 5
Start / End Page
- 972 - 980
PubMed ID
- 2669986
International Standard Serial Number (ISSN)
- 0006-3363
Digital Object Identifier (DOI)
- 10.1095/biolreprod40.5.972
Language
- eng
Conference Location
- United States