The hypogonadotropic state of the prepubertal male rhesus monkey (Macaca mulatta) is not associated with a decrease in hypothalamic gonadotropin-releasing hormone content.

Published

Journal Article

Hypothalamic contents of gonadotropin-releasing hormone (GnRH) in neonatally orchidectomized infant, juvenile, and adult monkeys were measured by a radioimmunoassay (RIA) and by an in vivo bioassay that utilized luteinizing hormone (LH) secretion in estrogen- and progesterone-treated ovariectomized rats. The results of the bioassay provided no evidence to suggest that hypothalamic GnRH content in juvenile monkeys (mean = 83 ng/hypothalamus; n = 3) was less than that in infants (mean = 54 ng/hypothalamus; n = 4) and adults (mean = 36 ng/hypothalamus; n = 3). A similar developmental pattern in hypothalamic GnRH content was also observed when the decapeptide was measured by RIA. In striking contrast to the maintenance of hypothalamic GnRH content throughout postnatal development, pituitary gonadotropin contents and serum gonadotropin concentrations were markedly reduced in juvenile monkeys.

Full Text

Duke Authors

Cited Authors

  • Fraser, MO; Pohl, CR; Plant, TM

Published Date

  • May 1989

Published In

Volume / Issue

  • 40 / 5

Start / End Page

  • 972 - 980

PubMed ID

  • 2669986

Pubmed Central ID

  • 2669986

International Standard Serial Number (ISSN)

  • 0006-3363

Digital Object Identifier (DOI)

  • 10.1095/biolreprod40.5.972

Language

  • eng

Conference Location

  • United States