Development of an experimental system for the study of urethral biomechanical function.

Published

Journal Article

Despite its principal mechanical function in the storage and release of urine, the biomechanical properties of the urethra have remained largely unexplored. The purpose of this study was to develop and validate an experimental model that can be used for evaluating whole urethral tissue in such a manner. Bladder-urethral specimens were excised from halothane-anesthetized female rats and mounted at in vivo length within the experimental apparatus consisting of a tissue perfusion chamber, an adjustable fluid column, and a laser micrometer. Outer diameter measurements were made at proximal, mid, and distal axial locations in response to increases in intraluminal pressure and after addition of various muscle-responsive agents. Basal smooth muscle tone and regional variations in compliance were detected through pressure-diameter responses. Chemically evoked contractile responses were measured and correspond to regional compositions of intrinsic smooth and striated muscle components. The results presented illustrate the utility of this system, which should permit a more thorough characterization of structure-function relationships and urethral biomechanical function in relation to normal and dysfunctional tissue states.

Full Text

Duke Authors

Cited Authors

  • Jankowski, RJ; Prantil, RL; Fraser, MO; Chancellor, MB; De Groat, WC; Huard, J; Vorp, DA

Published Date

  • February 2004

Published In

Volume / Issue

  • 286 / 2

Start / End Page

  • F225 - F232

PubMed ID

  • 14506075

Pubmed Central ID

  • 14506075

International Standard Serial Number (ISSN)

  • 1931-857X

Digital Object Identifier (DOI)

  • 10.1152/ajprenal.00126.2003

Language

  • eng

Conference Location

  • United States