Platelet alpha 2-adrenergic receptors in schizophrenic patients before and after phenothiazine treatment.


Journal Article

The specific binding to isolated platelet membranes of 3H-clonidine, an alpha 2-adrenergic receptor partial agonist, and 3H-yohimbine, an alpha 2-adrenergic receptor antagonist, was measured in male, drug-free schizophrenic patients. The maximum number of binding sites (Bmax) for 3H-yohimbine was significantly lower in these patients than in normal subjects. Treatment with chlorpromazine (CPZ) for 2 weeks further decreased the Bmax for both ligands. Plasma catecholamine levels were determined before and after treatment. Before treatment, levels of dopamine and norepinephrine (NE) were within a normal range, while epinephrine (E) levels were significantly elevated. CPZ treatment significantly increased plasma NE levels, but decreased E levels to a normal range. These observations suggest that schizophrenia might be associated with abnormal noradrenergic function that is reflected by a decreased number of platelet alpha 2-adrenergic receptors.

Full Text

Duke Authors

Cited Authors

  • Rice, HE; Smith, CB; Silk, KR; Rosen, J

Published Date

  • May 1, 1984

Published In

Volume / Issue

  • 12 / 1

Start / End Page

  • 69 - 77

PubMed ID

  • 6087398

Pubmed Central ID

  • 6087398

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/0165-1781(84)90139-2


  • eng

Conference Location

  • Ireland