Platelet alpha-2-adrenergic dysfunction in negative symptom schizophrenia: a preliminary study.

Journal Article (Journal Article)

The specific binding to platelet membranes (Bmax) of 3H-clonidine, an alpha-2 agonist, and 3H-yohimbine, an alpha-2 antagonist, was measured in nine drug-free male schizophrenic patients and repeated after 2 weeks of chlorpromazine (CPZ) treatment. Patients with a lower pretreatment Bmax for 3H-clonidine showed a significantly smaller change in Bmax after treatment, less improvement in their clinical state, as indicated by the change in the Global Assessment Scale (GAS), and a lower posttreatment GAS. Also, they had a significantly higher score for negative symptoms on the Affect Rating Scale both before and after treatment. These findings suggest that schizophrenic patients with relatively subsensitive platelet alpha-2-adrenergic receptors, as measured by 3H-clonidine binding, tend to have more negative symptoms and a diminished alpha receptor binding response and diminished clinical response to CPZ. There were no clinical correlations to 3H-yohimbine binding.

Full Text

Duke Authors

Cited Authors

  • Rosen, J; Silk, KR; Rice, HE; Smith, CB

Published Date

  • May 1, 1985

Published In

Volume / Issue

  • 20 / 5

Start / End Page

  • 539 - 545

PubMed ID

  • 2985130

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/0006-3223(85)90025-3


  • eng

Conference Location

  • United States