Reconstruction with vascularized composite tissue in patients with excessive injury following surgery and irradiation.

Journal Article (Journal Article)

The biological effects of a single high dose of radiation are examined. Both cellular injury and repair are reviewed during early, intermediate, and late phases. Anticipated composite tissue morbidity is detailed for therapeutic radiation doses administered to the head and neck, breast and thorax, and perineum. Patients who demonstrated excessive time-dose fractionation values were irradiated with lower x-ray energies. Those in whom there was an overlap of treatment fields presented a serious challenge to the reconstructive surgeon. Judicious selection of well-vascularized composite tissue outside the portals of irradiation, preferably with a long vascular pedicle, facilitated reconstruction. When possible, both donor and recipient vasculature should be outside the irradiated area to ensure uninterrupted blood flow to the transferred or transplanted tissue.

Full Text

Duke Authors

Cited Authors

  • Serafin, D; DeLand, M; Lesesne, CB; Smith, PJ; Noell, KT; Georgiade, N

Published Date

  • January 1, 1982

Published In

Volume / Issue

  • 8 / 1

Start / End Page

  • 35 - 54

PubMed ID

  • 7073192

International Standard Serial Number (ISSN)

  • 0148-7043

Digital Object Identifier (DOI)

  • 10.1097/00000637-198201000-00008


  • eng

Conference Location

  • United States