The structure of mononuclear phagocytes differentiating in vivo. III. The effect of particulate foreign substances.

Journal Article (Journal Article)

The response of mononuclear phagocytes to three inert particles--barium sulfate, talc, and thorium dioxide--was studied by correlated light and electron microscopy. All three particles induced maturation of the mononuclear phagocytes, which proceeded to the stage of the mature macrophage and required 7 to 9 days. Once established, maturation persisted as long as 45 days, as did the inert particles. The resultant lesions, dense aggregates of mature macrophages, were termed mature granulomas. The resultant maturation differed from that produced by digestible bacteria in tempo and extent but not in pattern.

Full Text

Duke Authors

Cited Authors

  • Goldner, RD; Adams, DO

Published Date

  • November 1977

Published In

Volume / Issue

  • 89 / 2

Start / End Page

  • 335 - 350

PubMed ID

  • 335889

Pubmed Central ID

  • PMC2032242

International Standard Serial Number (ISSN)

  • 0002-9440


  • eng

Conference Location

  • United States