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Postparathyroidectomy hypocalcemia as an accurate indicator of preparathyroidectomy bone histology in the uremic patient.

Publication ,  Journal Article
Felsenfeld, AJ; Gutman, RA; Llach, F; Harrelson, JM; Wells, SA
Published in: Miner Electrolyte Metab
1984

19 chronic renal failure patients underwent iliac crest bone biopsy prior to total parathyroidectomy with autotransplantation. The preoperative serum calcium concentration did not correlate with the number of osteoclasts/mm2 present on the preparathyroidectomy iliac biopsy. However, the postparathyroidectomy decrement in serum calcium (mg/dl and percent change) and the osteoclasts/mm2 were strongly correlated (p less than 0.001). In addition, the postoperative fall in serum calcium also correlated with the postoperative change in serum alkaline phosphatase (p less than 0.001). The nadir in postparathyroidectomy serum calcium was attained in a mean of 4.4 +/- 2.7 days. Our results indicate that the preoperative serum calcium concentration does not necessarily reflect active bone resorption, but the postoperative decrement in serum calcium provides an accurate index of preoperative histologic activity. The available data do not provide information with respect to the mechanism of postparathyroidectomy hypocalcemia since either the cessation of bone resorption, continued bone deposition, or a combination of both may be operative.

Duke Scholars

Published In

Miner Electrolyte Metab

ISSN

0378-0392

Publication Date

1984

Volume

10

Issue

3

Start / End Page

166 / 172

Location

Switzerland

Related Subject Headings

  • Urology & Nephrology
  • Postoperative Complications
  • Phosphorus
  • Parathyroid Hormone
  • Parathyroid Glands
  • Osteomalacia
  • Osteoclasts
  • Osteitis Fibrosa Cystica
  • Middle Aged
  • Male
 

Citation

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Felsenfeld, A. J., Gutman, R. A., Llach, F., Harrelson, J. M., & Wells, S. A. (1984). Postparathyroidectomy hypocalcemia as an accurate indicator of preparathyroidectomy bone histology in the uremic patient. Miner Electrolyte Metab, 10(3), 166–172.
Felsenfeld, A. J., R. A. Gutman, F. Llach, J. M. Harrelson, and S. A. Wells. “Postparathyroidectomy hypocalcemia as an accurate indicator of preparathyroidectomy bone histology in the uremic patient.Miner Electrolyte Metab 10, no. 3 (1984): 166–72.
Felsenfeld AJ, Gutman RA, Llach F, Harrelson JM, Wells SA. Postparathyroidectomy hypocalcemia as an accurate indicator of preparathyroidectomy bone histology in the uremic patient. Miner Electrolyte Metab. 1984;10(3):166–72.
Felsenfeld, A. J., et al. “Postparathyroidectomy hypocalcemia as an accurate indicator of preparathyroidectomy bone histology in the uremic patient.Miner Electrolyte Metab, vol. 10, no. 3, 1984, pp. 166–72.
Felsenfeld AJ, Gutman RA, Llach F, Harrelson JM, Wells SA. Postparathyroidectomy hypocalcemia as an accurate indicator of preparathyroidectomy bone histology in the uremic patient. Miner Electrolyte Metab. 1984;10(3):166–172.

Published In

Miner Electrolyte Metab

ISSN

0378-0392

Publication Date

1984

Volume

10

Issue

3

Start / End Page

166 / 172

Location

Switzerland

Related Subject Headings

  • Urology & Nephrology
  • Postoperative Complications
  • Phosphorus
  • Parathyroid Hormone
  • Parathyroid Glands
  • Osteomalacia
  • Osteoclasts
  • Osteitis Fibrosa Cystica
  • Middle Aged
  • Male