Vascularized tissue transfer for closure of irradiated wounds after soft tissue sarcoma resection.

Journal Article (Journal Article)

During the years 1985 to 1989, 82 patients were included in the soft tissue sarcoma protocol. Preoperative irradiation (50-54 Gy) was performed in all patients before tumor extirpation. Microwave hyperthermia was performed in conjunction with radiation in patients who had gross tumor remaining after initial biopsy. Primary closure with vascularized tissue (flaps) in lieu of conventional wound closure by skin approximation led to less complications (19% versus 51%), fewer secondary procedures for wound closure (10% versus 35%), shorter average hospitalization (15 versus 48 days) and greater limb salvage rate (97% versus 91%). The authors conclude that vascularized tissue (flaps) for primary wound closure in irradiated tissue leads to improved wound healing, and should be considered the procedure of choice for heavily irradiated soft tissue sarcoma defects.

Full Text

Duke Authors

Cited Authors

  • Barwick, WJ; Goldberg, JA; Scully, SP; Harrelson, JM

Published Date

  • November 1992

Published In

Volume / Issue

  • 216 / 5

Start / End Page

  • 591 - 595

PubMed ID

  • 1444651

Pubmed Central ID

  • PMC1242678

International Standard Serial Number (ISSN)

  • 0003-4932

Digital Object Identifier (DOI)

  • 10.1097/00000658-199211000-00011


  • eng

Conference Location

  • United States