The development of Lhermitte's sign during cisplatin chemotherapy. Possible drug-induced toxicity causing spinal cord demyelination.
Publication
, Journal Article
Walther, PJ; Rossitch, E; Bullard, DE
Published in: Cancer
November 1, 1987
Cisplatin is a recognized neurotoxic agent that commonly causes ototoxicity and peripheral neuropathy. In conjunction with characteristic peripheral neuropathy, two patients treated with high-dose cisplatin developed Lhermitte's sign, a manifestation of posterior column spinal cord pathology. After cisplatin therapy was stopped, this symptom gradually resolved. This suggests that at high doses cisplatin may also cause demyelinating central nervous system lesions involving the spinal cord.
Duke Scholars
Published In
Cancer
DOI
ISSN
0008-543X
Publication Date
November 1, 1987
Volume
60
Issue
9
Start / End Page
2170 / 2172
Location
United States
Related Subject Headings
- Spinal Cord Diseases
- Paresthesia
- Oncology & Carcinogenesis
- Male
- Humans
- Demyelinating Diseases
- Cisplatin
- Antineoplastic Combined Chemotherapy Protocols
- Aged
- Adult
Citation
APA
Chicago
ICMJE
MLA
NLM
Walther, P. J., Rossitch, E., & Bullard, D. E. (1987). The development of Lhermitte's sign during cisplatin chemotherapy. Possible drug-induced toxicity causing spinal cord demyelination. Cancer, 60(9), 2170–2172. https://doi.org/10.1002/1097-0142(19871101)60:9<2170::aid-cncr2820600909>3.0.co;2-n
Walther, P. J., E. Rossitch, and D. E. Bullard. “The development of Lhermitte's sign during cisplatin chemotherapy. Possible drug-induced toxicity causing spinal cord demyelination.” Cancer 60, no. 9 (November 1, 1987): 2170–72. https://doi.org/10.1002/1097-0142(19871101)60:9<2170::aid-cncr2820600909>3.0.co;2-n.
Walther PJ, Rossitch E, Bullard DE. The development of Lhermitte's sign during cisplatin chemotherapy. Possible drug-induced toxicity causing spinal cord demyelination. Cancer. 1987 Nov 1;60(9):2170–2.
Walther, P. J., et al. “The development of Lhermitte's sign during cisplatin chemotherapy. Possible drug-induced toxicity causing spinal cord demyelination.” Cancer, vol. 60, no. 9, Nov. 1987, pp. 2170–72. Pubmed, doi:10.1002/1097-0142(19871101)60:9<2170::aid-cncr2820600909>3.0.co;2-n.
Walther PJ, Rossitch E, Bullard DE. The development of Lhermitte's sign during cisplatin chemotherapy. Possible drug-induced toxicity causing spinal cord demyelination. Cancer. 1987 Nov 1;60(9):2170–2172.
Published In
Cancer
DOI
ISSN
0008-543X
Publication Date
November 1, 1987
Volume
60
Issue
9
Start / End Page
2170 / 2172
Location
United States
Related Subject Headings
- Spinal Cord Diseases
- Paresthesia
- Oncology & Carcinogenesis
- Male
- Humans
- Demyelinating Diseases
- Cisplatin
- Antineoplastic Combined Chemotherapy Protocols
- Aged
- Adult