Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice.

Journal Article

Spontaneous metastasis and extensive invasiveness were observed in athymic nude mice injected with human prostatic carcinoma cells of the PC-3 line or heterotransplants of nude mouse supported PC-3 tumor. In 3 experimental series, 60, 63 and 50 per cent of the nude mice receiving subcutaneous inoculations of PC-3 cells or tumor heterotransplants developed 1 or more lymphatic tumor metastases. Examination of metaphase-arrested cells recovered from the metastatic sites confirmed the tumor origin as human in each case. Cells recovered from 1 nude mouse supported subline, MPC-3-10, frequently exhibited double minute chromosomes in addition to the typical PC-3 chromosomal profile. These observations provide the foundation for a study of the relationship between prostate carcinoma cell characteristics and lymphatic metastasis in the nude mouse.

Full Text

Duke Authors

Cited Authors

  • Ware, JL; Paulson, DF; Mickey, GH; Webb, KS

Published Date

  • November 1, 1982

Published In

Volume / Issue

  • 128 / 5

Start / End Page

  • 1064 - 1067

PubMed ID

  • 7176035

International Standard Serial Number (ISSN)

  • 0022-5347

Language

  • eng

Conference Location

  • United States