Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice.
Published
Journal Article
Spontaneous metastasis and extensive invasiveness were observed in athymic nude mice injected with human prostatic carcinoma cells of the PC-3 line or heterotransplants of nude mouse supported PC-3 tumor. In 3 experimental series, 60, 63 and 50 per cent of the nude mice receiving subcutaneous inoculations of PC-3 cells or tumor heterotransplants developed 1 or more lymphatic tumor metastases. Examination of metaphase-arrested cells recovered from the metastatic sites confirmed the tumor origin as human in each case. Cells recovered from 1 nude mouse supported subline, MPC-3-10, frequently exhibited double minute chromosomes in addition to the typical PC-3 chromosomal profile. These observations provide the foundation for a study of the relationship between prostate carcinoma cell characteristics and lymphatic metastasis in the nude mouse.
Full Text
Duke Authors
Cited Authors
- Ware, JL; Paulson, DF; Mickey, GH; Webb, KS
Published Date
- November 1, 1982
Published In
Volume / Issue
- 128 / 5
Start / End Page
- 1064 - 1067
PubMed ID
- 7176035
Pubmed Central ID
- 7176035
International Standard Serial Number (ISSN)
- 0022-5347
Digital Object Identifier (DOI)
- 10.1016/s0022-5347(17)53345-5
Language
- eng
Conference Location
- United States