Detection of metastatic tumors in nude mice: brief communication.

Journal Article (Journal Article)

Homozygous nude (nu/nu) mice were inoculated ip with either highly malignant human bladder transitional cell carcinoma or human prostate adenocarcinoma. These animals were subsequently given injections of normal human T-lymphocytes to restore the known T-lymphocyte deficiency present in homozygous nude mice. Metastatic spread of the prostate and bladder carcinomas was evident in mice given human T-lymphocytes. Although tumor growth was observed at the sites of tumor inoculation, no tumor spread was observed in mice not receiving T-lymphocytes.

Full Text

Duke Authors

Cited Authors

  • Graham, SD; mickey, DD; Paulson, DF

Published Date

  • March 1, 1978

Published In

Volume / Issue

  • 60 / 3

Start / End Page

  • 715 - 716

PubMed ID

  • 304899

International Standard Serial Number (ISSN)

  • 0027-8874

Digital Object Identifier (DOI)

  • 10.1093/jnci/60.3.715


  • eng

Conference Location

  • United States