C-type virus particles in human urogenital tumours after heterotransplantation into nude mice.

Journal Article (Journal Article)

C-type viruses were formed in heterotransplants of 5/14 human urogenital tumours which had been serially transferred in nude mice of NIH(S) background. Except for one case in which C-type particles were present in the epithelial cells as well as the connective tissue, the viruses were only found within the stroma of the heterotransplanted tumours. Peroxidase labelling with anti-mouse serum demonstrated that the connective tissue supporting the transplanted human tumours was of mouse origin. Competition radioimmunoassays demonstrated that MuLV interspecies viral protein was present in high titre in the transplanted tumour extracts and also in extracts of 2 spontaneous mouse-tumour extracts. These data suggest that endogenous viruses of the nude mice are activated by the graft, and only subsequently infect the human tumour cells and form particles.

Full Text

Duke Authors

Cited Authors

  • Wunderli, H; Mickey, DD; Paulson, DF

Published Date

  • January 1, 1979

Published In

Volume / Issue

  • 39 / 1

Start / End Page

  • 35 - 42

PubMed ID

  • 215183

Pubmed Central ID

  • PMC2009797

International Standard Serial Number (ISSN)

  • 0007-0920

Digital Object Identifier (DOI)

  • 10.1038/bjc.1979.5


  • eng

Conference Location

  • England