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Management of metastatic prostatic cancer.

Publication ,  Journal Article
Paulson, DF
Published in: Urology
February 1985

Current management techniques for metastatic prostatic cancer have given rise to controversies regarding the optimal timing, form, and degree of androgen deprivation. Low-dose diethylstilbestrol (DES) or orchiectomy decrease serum testosterone levels while posing less cardiovascular risk than high-dose DES. LH-RH analogues, such as leuprolide or buserelin, also inhibit testosterone production. Some studies suggest that some tumor cells may be relatively, rather than absolutely, androgen dependent. This has been the rationale for the combined use of a pure antiandrogen and an LH-RH agonist. Unfortunately, while this combination has been found effective in previously untreated patients, it has not been equally effective in those who have undergone prior therapy and demonstrated disease progression.

Duke Scholars

Published In

Urology

ISSN

0090-4295

Publication Date

February 1985

Volume

25

Issue

2 Suppl

Start / End Page

49 / 52

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Neoplasm Metastasis
  • Male
  • Leuprolide
  • Humans
  • Hormones
  • Gonadotropin-Releasing Hormone
  • Estramustine
  • Diethylstilbestrol
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Paulson, D. F. (1985). Management of metastatic prostatic cancer. Urology, 25(2 Suppl), 49–52.
Paulson, D. F. “Management of metastatic prostatic cancer.Urology 25, no. 2 Suppl (February 1985): 49–52.
Paulson DF. Management of metastatic prostatic cancer. Urology. 1985 Feb;25(2 Suppl):49–52.
Paulson, D. F. “Management of metastatic prostatic cancer.Urology, vol. 25, no. 2 Suppl, Feb. 1985, pp. 49–52.
Paulson DF. Management of metastatic prostatic cancer. Urology. 1985 Feb;25(2 Suppl):49–52.
Journal cover image

Published In

Urology

ISSN

0090-4295

Publication Date

February 1985

Volume

25

Issue

2 Suppl

Start / End Page

49 / 52

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Neoplasm Metastasis
  • Male
  • Leuprolide
  • Humans
  • Hormones
  • Gonadotropin-Releasing Hormone
  • Estramustine
  • Diethylstilbestrol