The effects of castration on adrenal testosterone secretion in men with prostatic carcinoma.


Journal Article

Selective adrenal vein catheterization was done on intact and castrated men with prostatic carcinoma. Adrenal to peripheral venous testosterone gradients were observed in all patients, indicating adrenal production of this hormone. No compensatory adrenal production of testosterone was noted during a 17-month period after orchiectomy. The data suggest that the human adrenal in castrates produces testosterone, which may explain why adrenal ablation can offer palliation in some patients with prostatic carcinoma.

Full Text

Duke Authors

Cited Authors

  • Sanford, EJ; Paulson, DF; Rohner, TJ; Santen, RJ; Bardin, CW

Published Date

  • December 1, 1977

Published In

Volume / Issue

  • 118 / 6

Start / End Page

  • 1019 - 1021

PubMed ID

  • 72830

Pubmed Central ID

  • 72830

International Standard Serial Number (ISSN)

  • 0022-5347

Digital Object Identifier (DOI)

  • 10.1016/s0022-5347(17)58283-x


  • eng

Conference Location

  • United States