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Does of stage pT0 cystectomy specimen confer a survival advantage in patients with minimally invasive bladder cancer?

Publication ,  Journal Article
Thrasher, JB; Frazier, HA; Robertson, JE; Paulson, DF
Published in: J Urol
August 1994

Controversy exists regarding the clinical significance of a pathological stage T0 (pT0) specimen found at cystectomy or after repeat transurethral resection for transitional cell carcinoma of the bladder. Many investigators cite this subpopulation of patients as a reason to consider more conservative management, based on the premise that the patient may have benefited from the original transurethral resection. However, we questioned whether outcome would be improved in stage pT0 cancer patients or whether outcome in stage pT0 cases would parallel that noted when the original stage was equivalent to the final pathological stage. To test this hypothesis, we examined the survival advantage occasioned by a stage pT0 finding in 66 of 433 patients who underwent radical cystectomy for transitional cell carcinoma of the bladder. Of the 433 patients studied 54 had clinical stage Tis or Ta, 166 clinical stage T1 and 213 clinical stage T2 disease. Within each of the 3 clinical groups (clinical stage Tis/Ta, clinical stage T1 and clinical stage T2) Kaplan-Meier survival projections were generated comparing patients with stage pT0 disease to those whose pathological stage was identical to the original clinical stage. Among the 54 clinical stage Tis/Ta cancer patients 11 with stage pT0 and 24 with stage pTis/pTa had survival projections of 90% of 5 years. Of 166 patients with clinical stage T1 disease 32 with stage pT0 and 78 with stage pT1 tumor had survival projections of 75% at 5 years. Among 213 patients with clinical stage T2 cancer 23 with stage pT0 and 71 with stage pT2 disease had survival projections of 68% at 5 years. The data suggest that a stage pT0 cystectomy specimen does not confer a survival advantage over that noted from the initiating population in which the final pathological stage and initial clinical stage are equivalent. A patient with a stage pT0 specimen functions, by survival analysis, in a manner similar to one with the stated clinical stage.

Duke Scholars

Published In

J Urol

DOI

ISSN

0022-5347

Publication Date

August 1994

Volume

152

Issue

2 Pt 1

Start / End Page

393 / 396

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urinary Bladder Neoplasms
  • Treatment Outcome
  • Survival Rate
  • Retrospective Studies
  • Neoplasm Staging
  • Neoplasm Invasiveness
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Thrasher, J. B., Frazier, H. A., Robertson, J. E., & Paulson, D. F. (1994). Does of stage pT0 cystectomy specimen confer a survival advantage in patients with minimally invasive bladder cancer? J Urol, 152(2 Pt 1), 393–396. https://doi.org/10.1016/s0022-5347(17)32746-5
Thrasher, J. B., H. A. Frazier, J. E. Robertson, and D. F. Paulson. “Does of stage pT0 cystectomy specimen confer a survival advantage in patients with minimally invasive bladder cancer?J Urol 152, no. 2 Pt 1 (August 1994): 393–96. https://doi.org/10.1016/s0022-5347(17)32746-5.
Thrasher JB, Frazier HA, Robertson JE, Paulson DF. Does of stage pT0 cystectomy specimen confer a survival advantage in patients with minimally invasive bladder cancer? J Urol. 1994 Aug;152(2 Pt 1):393–6.
Thrasher, J. B., et al. “Does of stage pT0 cystectomy specimen confer a survival advantage in patients with minimally invasive bladder cancer?J Urol, vol. 152, no. 2 Pt 1, Aug. 1994, pp. 393–96. Pubmed, doi:10.1016/s0022-5347(17)32746-5.
Thrasher JB, Frazier HA, Robertson JE, Paulson DF. Does of stage pT0 cystectomy specimen confer a survival advantage in patients with minimally invasive bladder cancer? J Urol. 1994 Aug;152(2 Pt 1):393–396.
Journal cover image

Published In

J Urol

DOI

ISSN

0022-5347

Publication Date

August 1994

Volume

152

Issue

2 Pt 1

Start / End Page

393 / 396

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urinary Bladder Neoplasms
  • Treatment Outcome
  • Survival Rate
  • Retrospective Studies
  • Neoplasm Staging
  • Neoplasm Invasiveness
  • Middle Aged
  • Male
  • Humans