Activation of cyclophosphamide for in vitro testing of cell sensitivity.
Publication
, Journal Article
Shrivastav, S; Stone, KR; Paulson, DF; Bonar, RA
Published in: Cancer Res
December 1980
Two methods are described for the activation of cyclophosphamide by a liver microsome preparation. These procedures were applicable to an assay in vitro which tests the sensitivity of tumor cells to the drug. Satisfactory results were obtained either by pretreatment of the cyclophosphamide and removal of the microsomes before testing or by the somewhat simpler procedure of mixing drug, microsomes, and test cells for the assay. Microsome treatment of bleomycin gave a smaller increase in activity, and much smaller effects were seen on some other drugs.
Duke Scholars
Published In
Cancer Res
ISSN
0008-5472
Publication Date
December 1980
Volume
40
Issue
12
Start / End Page
4443 / 4445
Location
United States
Related Subject Headings
- Urinary Bladder Neoplasms
- Oncology & Carcinogenesis
- Neoplasms, Experimental
- Microsomes, Liver
- Mice, Nude
- Mice
- Kidney Neoplasms
- Humans
- Drug Evaluation, Preclinical
- Cyclophosphamide
Citation
APA
Chicago
ICMJE
MLA
NLM
Shrivastav, S., Stone, K. R., Paulson, D. F., & Bonar, R. A. (1980). Activation of cyclophosphamide for in vitro testing of cell sensitivity. Cancer Res, 40(12), 4443–4445.
Shrivastav, S., K. R. Stone, D. F. Paulson, and R. A. Bonar. “Activation of cyclophosphamide for in vitro testing of cell sensitivity.” Cancer Res 40, no. 12 (December 1980): 4443–45.
Shrivastav S, Stone KR, Paulson DF, Bonar RA. Activation of cyclophosphamide for in vitro testing of cell sensitivity. Cancer Res. 1980 Dec;40(12):4443–5.
Shrivastav, S., et al. “Activation of cyclophosphamide for in vitro testing of cell sensitivity.” Cancer Res, vol. 40, no. 12, Dec. 1980, pp. 4443–45.
Shrivastav S, Stone KR, Paulson DF, Bonar RA. Activation of cyclophosphamide for in vitro testing of cell sensitivity. Cancer Res. 1980 Dec;40(12):4443–4445.
Published In
Cancer Res
ISSN
0008-5472
Publication Date
December 1980
Volume
40
Issue
12
Start / End Page
4443 / 4445
Location
United States
Related Subject Headings
- Urinary Bladder Neoplasms
- Oncology & Carcinogenesis
- Neoplasms, Experimental
- Microsomes, Liver
- Mice, Nude
- Mice
- Kidney Neoplasms
- Humans
- Drug Evaluation, Preclinical
- Cyclophosphamide