Regional changes in tissue pH and glucose content during cortical spreading depression in rat brain.


Journal Article

After eliciting a single passage of spreading depression in rat brain cortex, regional alterations in glucose content and tissue pH were studied in relation to changes in cortical steady potential. Migration of spreading depression into non-invaded cortex was accompanied by a drastic decrease in glucose concentration and tissue pH which persisted longer than the transient depolarization of cortical cells. This delay in metabolic recovery is probably accounted for by severe tissue acidosis which results from the stimulation of anaerobic glycolysis.

Full Text

Cited Authors

  • Csiba, L; Paschen, W; Mies, G

Published Date

  • June 1, 1985

Published In

Volume / Issue

  • 336 / 1

Start / End Page

  • 167 - 170

PubMed ID

  • 4005572

Pubmed Central ID

  • 4005572

Electronic International Standard Serial Number (EISSN)

  • 1872-6240

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(85)90430-5


  • eng