[Cerebral ischemia: ontogenetic differences in energy metabolism and protein biosynthesis].

Published

Journal Article

Are ontogenetic differences in the resistance of the brain towards ischemia reflected by differences in the postischemic disturbance of cerebral protein synthesis (PS) independently from energy metabolism (EM)?We studied hippocampal slices from immature (E60) and mature (E60) fetal guinea pigs as well as from adult guinea pigs. Cerebral EM and PS were measured during and up to 24 h after ischemia.After in vitro ischemia there was no inhibition in cerebral PS in immature fetuses, a transient inhibition in mature fetuses, and a permanent inhibition in adults. During and after in vitro ischemia cerebral EM was hardly disturbed in immature fetuses. No differences in cerebral EM could be observed between mature fetuses and adults.Ontogenetic differences in the resistance of the brain towards ischemia are reflected by differences in the postischemic disturbance of cerebral PS. The differences between mature fetuses and adults are independent from cerebral EM.

Full Text

Cited Authors

  • Berger, R; Djuricic, B; Jensen, A; Paschen, W

Published Date

  • January 1995

Published In

Volume / Issue

  • 35 Suppl 1 /

Start / End Page

  • 19 - 24

PubMed ID

  • 8672921

Pubmed Central ID

  • 8672921

Electronic International Standard Serial Number (EISSN)

  • 1423-0011

International Standard Serial Number (ISSN)

  • 1018-8843

Digital Object Identifier (DOI)

  • 10.1159/000272558

Language

  • ger