Neurologic deficit and cerebral ATP depletion after temporary focal ischemia in cats.


Journal Article

Focal ischemia was induced in 23 cats by occluding the left middle cerebral artery for 2 h. The animals were then divided into groups for unforced reperfusion of variable duration ranging from 2 to 48 h. Neurological ratings were obtained during both ischemia and reperfusion. Following planned sacrifice the regional ATP content was assessed by means of a bioluminescence method showing spatial distribution and degree of ATP depletion. All the animals developed a neurologic deficit, with a median of 6 points on a disability scale of 0-10. After reopening of the middle cerebral artery, neurologic recovery was quite variable depending on the initial neurologic deficit (partial phi = 0.67, p1 less than 0.05): Animals with mild initial functional impairment improved and those with severe neurologic disturbances either died early or developed a more severe neurologic deficit, irrespective of the duration of reperfusion. The degree of ATP depletion and the amount of brain tissue involved exhibited a significant correlation with the neurological outcome (tau = 0.50, p1 less than 0.05), but they were even more closely related to the initial neurologic deficit (partial phi = 1.00, p1 less than 0.001), suggesting an early definitive manifestation of deficiencies in regional energy metabolism.

Full Text

Cited Authors

  • Sato, M; Paschen, W; Pawlik, G; Heiss, WD

Published Date

  • June 1, 1984

Published In

Volume / Issue

  • 4 / 2

Start / End Page

  • 173 - 177

PubMed ID

  • 6725429

Pubmed Central ID

  • 6725429

Electronic International Standard Serial Number (EISSN)

  • 1559-7016

International Standard Serial Number (ISSN)

  • 0271-678X

Digital Object Identifier (DOI)

  • 10.1038/jcbfm.1984.25


  • eng