Spreading depression activates unfolded protein response.


Journal Article

Preconditioning is a process where a preceding non-lethal form of stress activates a stress response that protects cells against an otherwise lethal form of stress. Preconditioning can be induced in various ways including short-term ischemia or spreading depression. Here we investigated the effect of 1 h repetitive spreading depression on the unfolded protein response (UPR), a stress response activated under conditions associated with endoplasmic reticulum (ER) dysfunction. Spreading depression induced processing of xbp1 mRNA, indicative of an activation of UPR. Processing of xbp1 was paralleled by a rise in grp78 mRNA levels resulting from an activation of a signal transduction pathway that depends on protein synthesis. Preconditioning-induced activation of UPR may preserve ER functioning under pathological conditions interfering with ER functions.

Full Text

Cited Authors

  • Schneeloch, E; Wenkel, S; Mies, G; Paschen, W

Published Date

  • September 2004

Published In

Volume / Issue

  • 368 / 1

Start / End Page

  • 37 - 40

PubMed ID

  • 15342130

Pubmed Central ID

  • 15342130

Electronic International Standard Serial Number (EISSN)

  • 1872-7972

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2004.06.061


  • eng