The spindle assembly and spindle position checkpoints.

Journal Article (Journal Article;Review)

The mitotic spindle segregates chromosomes to opposite ends of the cell in preparation for cell division. Chromosome attachment to the spindle is monitored by the spindle assembly checkpoint, and at least in yeast cells, penetration of one spindle pole into the bud is monitored by the spindle position checkpoint. We review the historical origins of these checkpoints and recent progress in understanding their surveillance pathways. We also highlight fascinating but as yet unresolved questions, and examine crosstalk between the checkpoints.

Full Text

Duke Authors

Cited Authors

  • Lew, DJ; Burke, DJ

Published Date

  • 2003

Published In

Volume / Issue

  • 37 /

Start / End Page

  • 251 - 282

PubMed ID

  • 14616062

International Standard Serial Number (ISSN)

  • 0066-4197

Digital Object Identifier (DOI)

  • 10.1146/annurev.genet.37.042203.120656


  • eng

Conference Location

  • United States