Update on human alpha1-adrenoceptor subtype signaling and genomic organization.


Journal Article (Review)

Alpha1-adrenoceptors are G-protein-coupled receptors that bind catecholamines. Sixteen distinct human alpha1A-adrenoceptor isoforms have been identified from human tissues, including five full-length and 11 truncated versions. An updated scheme for the identification of alpha1A-adrenoceptor splice variants is proposed. Given the established roles of alpha1-adrenoceptors in benign prostatic hyperplasia, myocardial hypertrophy and other cardiovascular disorders, elucidation of the biological significance of the signaling diversity and potential pharmacological roles of alpha1A-adrenoceptor splice variants are important areas of future research.

Full Text

Cited Authors

  • Hawrylyshyn, KA; Michelotti, GA; Cogé, F; Guénin, S-P; Schwinn, DA

Published Date

  • September 2004

Published In

Volume / Issue

  • 25 / 9

Start / End Page

  • 449 - 455

PubMed ID

  • 15559245

Pubmed Central ID

  • 15559245

Electronic International Standard Serial Number (EISSN)

  • 1873-3735

International Standard Serial Number (ISSN)

  • 0165-6147

Digital Object Identifier (DOI)

  • 10.1016/j.tips.2004.06.011


  • eng