Electrochemical detection of nitric oxide in biological fluids.

Journal Article (Journal Article)

The challenges that must be overcome in order to detect nitric oxide (NO) in biological fluids include its low physiological concentration (1-nM) and its short half-life (a few seconds or less). Electrochemistry is capable of making such measurements, if certain principles, both biological and electrochemical, are kept in mind. We discuss these principles and demonstrate an example of practical measurement by detecting NO release in a drop of blood suspended within the reference electrode of an electrochemical cell. We elicit the NO release by decreasing the oxygen concentration in the gaseous atmosphere surrounding the drop.

Full Text

Duke Authors

Cited Authors

  • Allen, BW; Liu, J; Piantadosi, CA

Published Date

  • 2005

Published In

Volume / Issue

  • 396 /

Start / End Page

  • 68 - 77

PubMed ID

  • 16291222

International Standard Serial Number (ISSN)

  • 0076-6879

Digital Object Identifier (DOI)

  • 10.1016/S0076-6879(05)96007-2


  • eng

Conference Location

  • United States