Evaluation of a serological test for tuberculosis.


Journal Article

The agglutination test of Nicholls was found to be ineffective in diagnosing active tuberculosis. A positive result (titre of 1/125 or more) was found in the serum of 74 (70%) out of 105 patients with newly diagnosed, smear-positive pulmonary tuberculosis; 61 (62%) out of 98 healthy family contacts; and 19 (63%) out of 30 patients with non-tuberculous conditions. These findings were not due to faulty technique since the results obtained at Hammersmith were similar to those obtained by Nicholls's laboratory in the same serum samples. Twenty-seven of the tuberculous patients who had a negative result before treatment were retested two months after the start of chemotherapy but showed no evidence of a rising titre.

Full Text

Cited Authors

  • Mitchison, DA; Aber, VR; Ahmad, FJ; Allen, BW; Devi, S

Published Date

  • 1977-05-01

Published In

Volume / Issue

  • 1 / 6073

Start / End Page

  • 1383 - 1384

PubMed ID

  • 405075

Pubmed Central ID

  • 405075

International Standard Serial Number (ISSN)

  • 0007-1447

Digital Object Identifier (DOI)

  • 10.1136/bmj.1.6073.1383


  • eng