The penetration of dapsone, rifampicin, isoniazid and pyrazinamide into peripheral nerves.


Journal Article

1 Dapsone, rifampicin, isoniazid and pyrazinamide were shown to penetrate readily into the sciatic nerves of the dog and sheep. 2 These findings suggest that the continued persistence of viable drug-sensitive leprosy bacilli in the peripheral nerves of patients treated for long periods with either dapsone or rifampicin is not due to inadequate intraneural drug penetration.

Full Text

Cited Authors

  • Allen, BW; Ellard, GA; Gammon, PT; King, RC; McDougall, AC; Rees, RJ; Weddell, AG

Published Date

  • September 1, 1975

Published In

Volume / Issue

  • 55 / 1

Start / End Page

  • 151 - 155

PubMed ID

  • 1182342

Pubmed Central ID

  • 1182342

Electronic International Standard Serial Number (EISSN)

  • 1476-5381

International Standard Serial Number (ISSN)

  • 0007-1188

Digital Object Identifier (DOI)

  • 10.1111/j.1476-5381.1975.tb07623.x


  • eng