The correlation of bacteriophage types of Mycobacterium tuberculosis with guinea-pig virulence and in vitro-indicators of virulence.


Journal Article

Among 58 isoniazid-sensitive strains of Mycobacterium tuberculosis from India, Burma and East Africa, 23 were of phage type A, 31 of type I (intermediate), 4 of type B and none of type C. Type I strains differed from type A strains in being attenuated in the guinea-pig, susceptible to H2O2, sensitive to thiophen-2-carboxylic acid hydrazide and resistant to thiacetazone and p-aminosalicylic acid; the content of strongly acidic lipids and of sulphatide lipids was low and the attenuation indicator lipid was present. The pattern of results with the type B strains did not correspond to the patterns for types A or I. Strains of type I appear to be a distinct group within the species M. tuberculosis.

Full Text

Cited Authors

  • Grange, JM; Aber, VR; Allen, BW; Mitchison, DA; Goren, MB

Published Date

  • September 1, 1978

Published In

Volume / Issue

  • 108 / 1

Start / End Page

  • 1 - 7

PubMed ID

  • 80440

Pubmed Central ID

  • 80440

International Standard Serial Number (ISSN)

  • 0022-1287

Digital Object Identifier (DOI)

  • 10.1099/00221287-108-1-1


  • eng