Differential responsivity of monocyte cytokine and adhesion proteins in high- and low-hostile humans.

Journal Article (Academic article)

This study tested the general hypothesis that high- and low-hostile respondents would show different patterns of change in monocyte cytokine and adhesion protein (MCAP) expression in response to pharmacologically induced alterations in sympathetic nervous system (SNS) and parasympathetic nervous system (PNS) balance. On 3 separate days, 4 high- and 4 low-hostile respondents received isoproterenol infusions after saline, atropine (PNS blockade), or neostigmine (PNS stimulation) pre-treatment. Dual color flow cytometry with fluorescently labeled monoclonal antibodies to CD 14 (monocyte market), interleukin-1, leukocyte function activator (LFA-1), Class II major histocompatibility complex (MHC-II), and tumor necrosis factor was used to quantify cytokine and adhesion protein expression on monocytes in blood samples drawn before and after the combination drug infusions on the 3 test days in each respondents. Following PNS stimulation and istoproterenol infusion there was a decrease (compared to saline pretreatment) in MHC II expression in high hostiles that was significantly (p

Duke Authors

Cited Authors

  • Williams, RB; Sasaki, M; Lewis, JG; Kuhn, CM; Schanberg, SM; Suarez, EC; Feaganes, JR; Adams, DO

Published Date

  • 1997

Published In

Volume / Issue

  • 4 / 3

Start / End Page

  • 264 - 272

PubMed ID

  • 16250732

International Standard Serial Number (ISSN)

  • 1070-5503

Conference Location

  • united states