Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets.

Journal Article (Journal Article)

The C57BL/6J mouse develops obesity and diabetes in response to a high-fat, high-simple carbohydrate diet. To determine the dynamics of glucose-induced insulin release in this animal model of NIDDM, we studied the acute insulin response to glucose of perifused islets in C57BL/6J (diabetes-prone) and A/J (diabetes-resistant) mice fed a normal control diet and of others fed a diabetogenic diet. The insulin response of normal C57BL/6J islets was almost monophasic, with a deficiency in the second phase during high glucose stimulation when compared to that of A/J control islets. The defect in C57BL/6J mice was exaggerated in animals fed a diabetogenic diet. It is suggested that a latent deficiency of second phase insulin release may contribute to the development of the diet-induced syndrome in this model.

Full Text

Duke Authors

Cited Authors

  • Wencel, HE; Smothers, C; Opara, EC; Kuhn, CM; Feinglos, MN; Surwit, RS

Published Date

  • June 1995

Published In

Volume / Issue

  • 57 / 6

Start / End Page

  • 1215 - 1220

PubMed ID

  • 7652047

International Standard Serial Number (ISSN)

  • 0031-9384

Digital Object Identifier (DOI)

  • 10.1016/0031-9384(95)00022-b


  • eng

Conference Location

  • United States