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The relationship between hostility and beta-adrenergic receptor physiology in health young males.

Publication ,  Journal Article
Suarez, EC; Shiller, AD; Kuhn, CM; Schanberg, S; Williams, RB; Zimmermann, EA
Published in: Psychosom Med
1997

OBJECTIVE: We examined the relationship between hostility and mononuclear leukocyte (MNL) beta-adrenergic receptor function in a sample of young healthy males. METHOD: Thirty subjects were selected for having scored above 20 (N = 11) and below 14 (N = 19) on the Cook-Medley Hostility (Ho) scale. MNL beta-adrenergic receptor function was characterized in terms of receptor density (Bmax) and ligand-binding affinity (Kd) in homogenized cells, and intracellular cyclic adenosine monophosphate (cAMP) responses to saline, isoproterenol, and forskolin in whole cells. Subjects also completed the Multidimensional Anger Inventory (MAI), which assesses dimensions of anger. RESULTS: Relative to men with low Ho scores, men with Ho scores above 20 showed lower receptor number and greater forskolin-stimulated cAMP. Moreover, high hostile men reported a greater frequency of anger, longer duration of anger, more frequent brooding, and a hostile outlook. CONCLUSIONS: These data indicate that adrenergic receptor down-regulation is associated with hostility. This association may be linked to hostile persons' propensity for excessive and prolonged neuroendocrine responses to either psychological stressors or the experience of chronic stress associated with frequent and prolonged bouts of anger.

Duke Scholars

Published In

Psychosom Med

DOI

ISSN

0033-3174

Publication Date

1997

Volume

59

Issue

5

Start / End Page

481 / 487

Location

United States

Related Subject Headings

  • Social Perception
  • Regression Analysis
  • Receptors, Adrenergic, beta
  • Psychiatry
  • Male
  • Leukocytes, Mononuclear
  • Humans
  • Hostility
  • Cyclic AMP
  • Colforsin
 

Citation

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Suarez, E. C., Shiller, A. D., Kuhn, C. M., Schanberg, S., Williams, R. B., & Zimmermann, E. A. (1997). The relationship between hostility and beta-adrenergic receptor physiology in health young males. Psychosom Med, 59(5), 481–487. https://doi.org/10.1097/00006842-199709000-00004
Suarez, E. C., A. D. Shiller, C. M. Kuhn, S. Schanberg, R. B. Williams, and E. A. Zimmermann. “The relationship between hostility and beta-adrenergic receptor physiology in health young males.Psychosom Med 59, no. 5 (1997): 481–87. https://doi.org/10.1097/00006842-199709000-00004.
Suarez EC, Shiller AD, Kuhn CM, Schanberg S, Williams RB, Zimmermann EA. The relationship between hostility and beta-adrenergic receptor physiology in health young males. Psychosom Med. 1997;59(5):481–7.
Suarez, E. C., et al. “The relationship between hostility and beta-adrenergic receptor physiology in health young males.Psychosom Med, vol. 59, no. 5, 1997, pp. 481–87. Pubmed, doi:10.1097/00006842-199709000-00004.
Suarez EC, Shiller AD, Kuhn CM, Schanberg S, Williams RB, Zimmermann EA. The relationship between hostility and beta-adrenergic receptor physiology in health young males. Psychosom Med. 1997;59(5):481–487.

Published In

Psychosom Med

DOI

ISSN

0033-3174

Publication Date

1997

Volume

59

Issue

5

Start / End Page

481 / 487

Location

United States

Related Subject Headings

  • Social Perception
  • Regression Analysis
  • Receptors, Adrenergic, beta
  • Psychiatry
  • Male
  • Leukocytes, Mononuclear
  • Humans
  • Hostility
  • Cyclic AMP
  • Colforsin