Post-prenylation-processing enzymes as new targets in oncogenesis.

Journal Article (Review)

RAS and many other oncogenic proteins undergo a complex series of post-translational modifications that are initiated by the addition of an isoprenoid lipid through a process known as prenylation. Following prenylation, these proteins usually undergo endoproteolytic processing by the RCE1 protease and then carboxyl methylation by a unique methyltransferase known as isoprenylcysteine carboxyl methyltransferase (ICMT). Although inhibitors that have been designed to target the prenylation step are now in advanced-stage clinical trials, their utility and efficacy seem to be limited. Recent findings, however, indicate that the inhibition of these post-prenylation-processing steps--particularly that of ICMT-catalysed methylation--might provide a better approach to the control of cancer-cell proliferation.

Full Text

Duke Authors

Cited Authors

  • Winter-Vann, AM; Casey, PJ

Published Date

  • May 2005

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 405 - 412

PubMed ID

  • 15864282

International Standard Serial Number (ISSN)

  • 1474-175X

Digital Object Identifier (DOI)

  • 10.1038/nrc1612


  • eng

Conference Location

  • England