Post-prenylation-processing enzymes as new targets in oncogenesis.
Journal Article (Review)
RAS and many other oncogenic proteins undergo a complex series of post-translational modifications that are initiated by the addition of an isoprenoid lipid through a process known as prenylation. Following prenylation, these proteins usually undergo endoproteolytic processing by the RCE1 protease and then carboxyl methylation by a unique methyltransferase known as isoprenylcysteine carboxyl methyltransferase (ICMT). Although inhibitors that have been designed to target the prenylation step are now in advanced-stage clinical trials, their utility and efficacy seem to be limited. Recent findings, however, indicate that the inhibition of these post-prenylation-processing steps--particularly that of ICMT-catalysed methylation--might provide a better approach to the control of cancer-cell proliferation.
Full Text
Duke Authors
Cited Authors
- Winter-Vann, AM; Casey, PJ
Published Date
- May 2005
Published In
Volume / Issue
- 5 / 5
Start / End Page
- 405 - 412
PubMed ID
- 15864282
International Standard Serial Number (ISSN)
- 1474-175X
Digital Object Identifier (DOI)
- 10.1038/nrc1612
Language
- eng
Conference Location
- England