Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.

Published

Journal Article

Protein farnesyltransferase (FTase) is an enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif. Farnesylation allows substrates to interact with membranes and protein targets. Using gene-targeted mice, we report that FTase is essential for embryonic development, but dispensable for adult homeostasis. Six-month-old FTase-deficient mice display delayed wound healing and maturation defects in erythroid cells. Embryonic fibroblasts lacking FTase have a flat morphology and reduced motility and proliferation rates. Ablation of FTase in two ras oncogene-dependent tumor models has no significant consequences for tumor initiation. However, elimination of FTase during tumor progression had a limited but significant inhibitory effect. These results should help to better understand the role of protein farnesylation in normal tissues and in tumor development.

Full Text

Duke Authors

Cited Authors

  • Mijimolle, N; Velasco, J; Dubus, P; Guerra, C; Weinbaum, CA; Casey, PJ; Campuzano, V; Barbacid, M

Published Date

  • April 2005

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • 313 - 324

PubMed ID

  • 15837621

Pubmed Central ID

  • 15837621

International Standard Serial Number (ISSN)

  • 1535-6108

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2005.03.004

Language

  • eng

Conference Location

  • United States