Systematic assignment of the configuration of flexible natural products by spectroscopic and computational methods: the bistramide C analysis.

Journal Article (Journal Article)

[reaction: see text] The combination of NMR NOE, chemical shift, and J-coupling measurements with molar rotation and circular dichroism (CD) determinations, including RI-DFT BP86/aug-cc-pVDZ calculations, reduced a candidate pool of 1024 possible stereoisomers of (+)-bistramide C to a single absolute configuration assignment for the 10 stereogenic carbons of the marine natural product.

Full Text

Duke Authors

Cited Authors

  • Zuber, G; Goldsmith, M-R; Hopkins, TD; Beratan, DN; Wipf, P

Published Date

  • November 2005

Published In

Volume / Issue

  • 7 / 23

Start / End Page

  • 5269 - 5272

PubMed ID

  • 16268555

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol052154v


  • eng