Association of misexpression with sterility in hybrids of Drosophila simulansand D. mauritiana.

Journal Article (Letter)

Recent studies have identified genes associated with hybrid sterility and other hybrid dysfunctions, but the consequences of introgressions of these "speciation genes" are often poorly understood. Previously, we identified a panel of genes that are underexpressed in sterile male hybrids of Drosophila simulans and D. mauritiana relative to pure species. Here, we build on this reverse-genetics approach to demonstrate that the underexpression of at least five of these genes in hybrids is associated with hybrid sterility and that these five genes are coordinately regulated. We map one upstream regulator of these genes to a region previously shown to harbor one or more factors causing hybrid sterility. Finally, we show that the genes underexpressed in hybrids are often highly conserved, as might be predicted for downstream targets of the genetic changes that cause hybrid sterility. This approach integrates forward genetics with reverse genetics to show a proximate consequence of the introgression of particular hybrid sterility-conferring regions between species: underexpression of genes necessary for normal spermatogenesis.

Full Text

Duke Authors

Cited Authors

  • Michalak, P; Noor, MAF

Published Date

  • August 2004

Published In

Volume / Issue

  • 59 / 2

Start / End Page

  • 277 - 282

PubMed ID

  • 15486701

Electronic International Standard Serial Number (EISSN)

  • 1432-1432

International Standard Serial Number (ISSN)

  • 0022-2844

Digital Object Identifier (DOI)

  • 10.1007/s00239-004-2622-y


  • eng