Creutzfeldt-Jakob disease in a pregnant woman with an implanted dura mater graft.

Journal Article (Journal Article)

A 28-year-old woman with prior neurosurgery involving the placement of a cadaveric dural graft developed a rapidly progressive neurodegenerative disorder with prominent cerebellar dysfunction that was proven at autopsy to be Creutzfeldt-Jakob disease. She represents the second American to develop Creutzfeldt-Jakob disease in association with a dural graft. The unusual features of the case include the patient's initial clinical presentation with cerebellar ataxia in the absence of dementia, the widespread presence of kuru-type amyloid plaques on a histological examination of the brain, the development of clinical symptoms during pregnancy, and the subsequent delivery of a child who remains healthy at the age of 3 years.

Full Text

Duke Authors

Cited Authors

  • Lane, KL; Brown, P; Howell, DN; Crain, BJ; Hulette, CM; Burger, PC; DeArmond, SJ

Published Date

  • April 1994

Published In

Volume / Issue

  • 34 / 4

Start / End Page

  • 737 - 739

PubMed ID

  • 8008176

Electronic International Standard Serial Number (EISSN)

  • 1524-4040

International Standard Serial Number (ISSN)

  • 0148-396X

Digital Object Identifier (DOI)

  • 10.1227/00006123-199404000-00026


  • eng