Immunological aspects of Alzheimer disease: a review.


Journal Article (Review)

Clinical and neuropathological similarities between Alzheimer disease and the transmissible spongiform encephalopathies have sparked intensive investigation of the role of nearly every arm of the immune system in the etiology and pathogenesis of Alzheimer disease. These endeavors have yielded intriguing results but no clear-cut answers. Studies of humoral and cellular immune function in patients with dementia of the Alzheimer type (DAT), immunohistochemical examinations of Alzheimer brain tissue and HLA typing of both sporadic and familial DAT are reviewed. Sporadic DAT appears to be associated with the complement allotype C4B2 in the major histocompatibility complex, which is linked very closely to HLA. Mechanisms for the role of complement in the pathogenesis of DAT are postulated.

Full Text

Cited Authors

  • Hulette, CM; Walford, RL

Published Date

  • 1987

Published In

Volume / Issue

  • 1 / 2

Start / End Page

  • 72 - 82

PubMed ID

  • 3331113

Pubmed Central ID

  • 3331113

International Standard Serial Number (ISSN)

  • 0893-0341

Digital Object Identifier (DOI)

  • 10.1097/00002093-198701020-00002


  • eng

Conference Location

  • United States