Evaluation of cerebral biopsies for the diagnosis of dementia.

Published

Journal Article

To identify those patients most likely to benefit from a cerebral biopsy to diagnose dementia, we reviewed a series of 14 unselected biopsies performed during a 9-year period (1980 through 1989) at Duke University Medical Center, Durham, NC. Pathognomonic features allowed a definitive diagnosis in seven specimens. Nondiagnostic abnormalities but not diagnostic neuropathologic changes were seen in five additional specimens, and two specimens were normal. Creutzfeldt-Jakob disease was the most frequent diagnosis. One patient each was diagnosed as having Alzheimer's disease, diffuse Lewy body disease, adult-onset Niemann-Pick disease, and anaplastic astrocytoma. We conclude that a substantial proportion of patients presenting clinically with atypical dementia are likely to receive a definitive diagnosis from a cerebral biopsy. However, in those with coexisting hemiparesis, chorea, athetosis, or lower motor neuron signs, cerebral biopsies are less likely to be diagnostic.

Full Text

Duke Authors

Cited Authors

  • Hulette, CM; Earl, NL; Crain, BJ

Published Date

  • January 1, 1992

Published In

Volume / Issue

  • 49 / 1

Start / End Page

  • 28 - 31

PubMed ID

  • 1728259

Pubmed Central ID

  • 1728259

International Standard Serial Number (ISSN)

  • 0003-9942

Language

  • eng

Conference Location

  • United States